NEUROMUSCULAR DISORDERS & MUSCLE WASTING DISEASES

Building the clinical standard for muscle quality measurement to aid muscle wasting and neuromuscular disorder diagnosis

Quantitative.   Painless.   Low Cost.   Measure@Home.  MRI Alternative.

Our driving goal is to assess, monitor, and display changes in skeletal muscle composition and structure to aid in the diagnosis, prognosis, and treatment of neuromuscular and musculoskeletal diseases. We are deeply committed to help the dedicated clinicians, scientists, caregivers, and above all, patients who are battling these diseases, each and every day. 

Neuromuscular Disorders are Growing.

Muscle Wasting is Skyrocketing.

  • ALS will increase 69% by 2040

  • Americans 65+ will reach 72M by 2030. Up to 30% will get sarcopenia  

  • Muscle wasting increases fall risk… #1 cause of elderly injury death

  • 30M U.S. people projected to use GLP-1 obesity drugs by 2030 (JP Morgan). 

Many Clinical Unmet Needs

No quantitative, comprehensive biomarker for measuring and monitoring neuromuscular disorders. 

Current tools not sensitive and frequent enough to “see” early, single muscle changes.

“Diagnostic delay” can range 9-24 months from the time ALS symptoms first manifest.

MRI, now widely used to measure muscle conditions, is used infrequently, expensive, non-portable, and often traumatic.

Other muscle measures are invasive, in-clinic, and infrequent for monitoring or insensitive, not easily transportable, or not single muscle specific.

Clinicians are now seeking in-home measurements for better patient compliance, diversity, and more frequent data.

Quantitative

Provides quantitative data on functional capability while the muscle and subject remain entirely at rest.

 

portable

Portable non-invasive device that scans a muscle in a matter of seconds.

Painless

EIM engages painless, active monitoring. 

comprehensive

One holistic measure of both muscle composition and infrastructure.

MYOLEX BY THE NUMBERS

Five breakthroughs help make the impossible… Possible

Quantitative & Comprehensive

   Quantitative device that non-invasively and comprehensively measures a single muscle’s full composition and micro architecture

Aid Earlier ALS Diagnosis

 Highly sensitive, more frequently available, device that could assist clinical researchers in identifying ALS diseased muscles earlier**   

MRI Alternative for Muscles

  Alternative device that could replace* and/or augment magnetic resonance imaging (MRI) as the lead measurement device for upper and lower extremities, abdomen, shoulder, and hip muscles

Smaller Clinical Trials

   Highly accurate, sensitive, and reproducible muscle condition assessment tool that enables pharmaceutical companies to conduct smaller, faster, more diverse clinical trials

Painless. Easy-to-Use. @Home

 Painless, portable, and easy-to-use muscle measurement device that remote subjects and their caregivers can use at home

*Requires FDA Approval.

**In mouse model research study, EIM identified ALS muscle deterioration very early at 8 weeks, four to six weeks earlier than other clinical standard muscle measures.

Why EIM is a Superior Muscle Assessment

Painlessly measures muscle composition and micro infrastructure

COMPREHENSIVE & HOLISTIC

MEASURES SINGLE MUSCLES

EIM comprehensively measures alterations in electrical impedance that occur due to disease.

PAINLESS

Imperceptible, high-frequency electrical current passes through muscle across 4 blue electrodes.

Resulting voltage signals are measured across 2 yellow sense electrodes.

Smaller, Standardized Clinical Trials?

Myolex EIM has the potential to serve as a powerful, future biomarker that will be able to reduce clinical trial sample size requirements dramatically. Further, given it is non-invasive, portable, and easy-to-use, EIM enables standardized muscle condition data collection across all clinical trial sites.

Peer-reviewed studies have shown that the application of EIM to monitor ALS (Ref. 3) and DMD (Ref. 4) patients enables fewer patients to be enrolled in studies, as compared to the monitoring methods currently in use. 

Possible.

Myolex EIM. The First of Its Kind.

Available Today for Clinical Research

Extensive Clinical Research

Let’s Discover Together.

1309 Beacon Street, Suite 300

Brookline, MA 02446

Phone: 888.382.8824 

[email protected]